pentobarbital will decrease the level or effect of brexpiprazole samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Skärm Closely. Double brexpiprazole dose over 1-2 weeks if administered with a stark CYP3A4 inducer.pentobarbital will decrease the level or effect of propafenone ort affecting hepatic/intestinal enzyme C